Diet for Multiple Sclerosis should contain some dietary options, and vitamin D is one of the essential add-ons. It is seen that vitamin D is an effective treatment for prevention of multiple sclerosis in young adults, women, obese individuals, etc.

Vitamin D is a fat-soluble, vital vitamin that one can get from various dietary sources such as cereal products, fortified dairy, fish liver oil, animal protein as well as via sunlight exposure directly absorbed by the skin.

Vitamin D has an important immune-modulating role and is not only the most promising but also the most important dietary molecule for treating chronic inflammatory disorders such as multiple sclerosis. It is widely believed that the unique geographical distribution that multiple sclerosis has across the globe can be credited to the fact that vitamin D3 has reduced availability. This is because not all countries are sufficiently exposed to sunlight, so the absence of active vitamin D is a good reason for the geographical origins and distributions of the disease of multiple sclerosis.

However, one needs to remember that the lesser levels of active vitamin D could also not be there in the body due to the altered function or metabolism, and not just because of lack of sunlight exposure. In fact, the failure of supplementation of vitamin D3 to demonstrate significant effects on inflammatory diseases or body weight could be due to the tenacity of its deficiency despite its administration.

When one evaluates the efficacy of vitamin D supplementation in multiple sclerosis, one should consider the ensuing and subsequent polymorphisms affecting the vitamin D receptor (VDR), which has been associated recently with changes to gut permeability, inflammation, and obesity.

Moreover, the revelation that VDR-D triggers and stimulates the Sirtuin SIRT-1 to lead to suggest that vitamin D has a considerable effect on cell metabolism. Thus, it could be similar to other natural dietary supplements regarding its properties.